Exosomal MiR-1290 Promotes Angiogenesis of Hepatocellular Carcinoma via Targeting SMEK1

Figure 1

MiR-1290 is upregulated in serum-derived exosomes from HCC patients and cell lines. (a) Images of exosomes derived from HCC patient serum were captured by electron microscope. (b) The scatter diagram shows the differentially expressed miRNAs in exosomes derived from HCC patients and healthy individuals by RNA-sequencing. Red dots represent the upregulated miRNAs, green dots represent the downregulated miRNAs, and gray dots represent the unchanged miRNAs. (c) Detailed information of the significantly upregulated miRNAs are listed. (d, e) The expression levels of exosomal miR-1290 in serum from healthy individuals and HCC patients (d) and in HCC tissues and paired tumor adjacent tissues (e) were detected by qRT-PCR. (f) Cellular (left panel) and exosomal (right panel) miR-1290 levels in HCC and normal hepatic cell lines were assessed by qRT-PCR. ; ; . Ns, not significant.