A Risk Signature with Nine Stemness Index-Associated Genes for Predicting Survival of Patients with Uterine Corpus Endometrial Carcinoma

Figure 2

Identification and functional analysis of the mRNAsi-related genes in UCEC. (a) Cluster analysis of UCEC samples before and after removing outliers. Samples above the cut line are considered outliers. (b) Determination of soft threshold for the adjacency matrix. The scale-free topology model fit index and the mean connectivity for soft threshold powers (ß) were analyzed. (c) Identification of coexpression gene modules in UCEC. Different colors represent different gene modules. (d) Correlation between gene modules and clinical traits, including mRNAsi and EREG-mRNAsi. Each row corresponds to a different gene module. The numbers in each cell represent the correlation coefficient and value. Red and blue cells represent the positive and negative correlations between the gene module and the index, respectively. The color intensity indicates the correlation intensity. (e) The genes in the brown module correlated with mRNAsi (left) and EREG-mRNAsi (right). (f) Gene ontology analysis of genes in the brown module. The color of the bar represents the size of the value. The horizontal axis represents the number of genes involved in the function. (g) KEGG pathway enrichment analysis of genes in the brown module. The color of the bubble represents the value. The size of the bubble represents the number of genes involved in the pathway. The horizontal axis represents the percentage of genes involved in the pathway to all genes of the pathway. mRNAsi: mRNA expression-based stemness index; UCEC: uterine corpus endometrial carcinoma; KEGG: Kyoto Encyclopedia of Genes and Genomes.

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