ALKBH5 Gene Polymorphisms and Hepatoblastoma Susceptibility in Chinese Children

Table 2

Stratification analysis for the association between ALKBH5 genotypes and hepatoblastoma susceptibility.

Variables

rs1378602 (case/control)

AOR (95% CI)^a

rs8400 (case/control)

AOR (95% CI)^a

Combine genotypes (case/control)

AOR (95% CI)^a

GG

GA/AA

GG/GA

AA

0

1-2

Age, month

<17

151/532

24/129

0.65 (0.41–1.05)

0.077

141/550

34/111

1.21 (0.79–1.86)

0.381

54/206

121/455

1.02 (0.71–1.47)

0.908

≥17

126/678

23/137

0.90 (0.55–1.45)

0.651

116/672

33/143

1.34 (0.88–2.06)

0.177

39/258

110/557

1.31 (0.88–1.94)

0.181

Sex

Female

115/485

17/120

0.60 (0.35–1.03)

0.065

108/495

24/110

1.00 (0.61–1.63)

0.998

41/184

91/421

0.97 (0.64–1.45)

0.872

Male

162/725

30/146

0.91 (0.59–1.39)

0.648

149/727

43/144

1.46 (0.99–2.14)

0.054

52/280

140/591

1.28 (0.91–1.82)

0.161

Clinical stages

I + II

149/1210

24/266

0.72 (0.46–1.14)

0.159

147/1222

26/254

0.85 (0.55–1.32)

0.462

50/464

123/1012

1.12 (0.79–1.59)

0.512

III + IV

78/1210

13/266

0.77 (0.42–1.40)

0.387

65/1222

26/254

1.93 (1.20–3.10)

0.007

25/464

66/1012

1.21 (0.76–1.95)

0.425

AOR, adjusted odds ratio; CI, confidence interval. ^aAdjusted for age and sex, omitting the corresponding stratify factor.