CircRNF13 Promotes the Malignant Progression of Pancreatic Cancer through Targeting miR-139-5p/IGF1R Axis

Figure 2

CircRNF13 knockdown inhibits pancreatic cancer cell proliferation and invasion. (a) The expression of circRNF13 in circRNF13-silenced PC cells. (b, c) CCK-8 assay was conducted on MIA-PaCa-2 or PANC-1 cell lines transfected with circRNF13 siRNA. indicates . (d, e) EdU assay was performed on MIA-PaCa-2 or PANC-1 cell lines. (f–i) Wound healing experiment displayed decreased invasive capability of MIA-PaCa-2 or PANC-1 cell lines after transfection of circRNF13-si1. (h, i) The quantification of wound healing experiment was shown in the form of bar plot. (j, l) Transwell migration (j) and invasion (l) assays were applied to evaluate the invasiveness and migration capabilities of circRNF13-silenced PC cells. (k, m) The quantification of Transwell migration (k) and invasion (m) assay was shown in the form of bar plot. indicates , indicates .

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