Identification of a Four-lncRNA Prognostic Signature for Colon Cancer Based on Genome Instability

Figure 2

Identification of lncRNAs associated with genome instability and their functional analysis in colon cancer. (a) The differential expression of the 20 most significantly upregulated and downregulated lncRNAs in GU and GS sets of colon cancer patients. (b) Based on the expression profile of 153 genome-instability-related lncRNAs, an unsupervised clustering analysis of 473 colon cancer patients was carried out. The red cluster represents GU-like group, while the blue cluster represents the GS-like group. (c) Boxplots indicating that GU-like group have a higher number of total somatic mutations. (d) The MLH1 expression of the GU-like group was significantly lower. (e) Coexpression network of mRNAs associated with genome-instability-related lncRNAs based on the Pearson correlation coefficient analysis. The red dots are mRNAs, and the blue nodes are lncRNAs. (f) GO and (g) KEGG of mRNAs coexpressed with genome-instability-related lncRNAs.

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