Overall Survival Analyses following Adjuvant Chemotherapy or Nonadjuvant Chemotherapy in Patients with Stage IB Non-Small-Cell Lung Cancer

Table 3

Univariable and multivariable analysis for OS using the Cox proportional hazard model in the non-ACT group.

	Univariate analysis			Multivariate analysis
	HR	95%C		HR	95%C
Gender
Male	1			1
Female	0.699	0.667–0.734	<0.001	0.701	0.666–0.737	<0.001
Age
<60	1			1
61–75	1.634	1.499–1.781	<0.001	1.504	1.379–1.641	<0.001
≥75	2.659	2.438–2.899	<0.001	2.329	2.132–2.544	<0.001
Race
White	1			1
Black	0.861	0.785–0.945	0.002	0.931	0.848–1.022	0.134
Others	0.765	0.690–0.848	<0.001	0.853	0.768–0.946	0.003
Marital status
Divorced	1			1
Married	0.922	0.853–0.997	0.042	0.822	0.759–0.890	<0.001
Others	1.071	0.987–1.163	0.100	0.990	0.911–1.076	0.816
Laterality
Left	1			—
Right	0.966	0.920–1.014	0.162	1.002	0.955–1.052	0.933
Grade
Well/moderate	1			1
Poor/undifferentiated	1.313	1.249–1.380	<0.001	1.216	1.155–1.279	<0.001
Unknown	0.784	0.703–0.874	<0.001	0.886	0.792–0.990	0.032
Pathological subtype
Adenocarcinoma	1			1
Squamous cell carcinoma	1.480	1.397–1.567	<0.001	1.285	1.210–1.364	<0.001
Others	0.903	0.853–0.957	0.001	0.929	0.875–0.985	0.014
Visceral pleural invasion
No	1			1
Yes	1.041	0.992–1.093	0.103	1.127	1.045–1.214	0.002
Tumor size (mm)
≤20	1			1
21–30	1.171	1.092–1.257	<0.001	1.195	1.112–1.284	<0.001
31–40	1.118	1.053–1.118	<0.001	1.269	1.167–1.380	<0.001
Surgical procedure
Lobectomy	1			1
Segmentectomy	1.653	1.563–1.749	<0.001	1.350	1.258–1.449	<0.001
No. of resected lymph nodes
0	1			1
1–3	0.699	0.643–0.760	<0.001	0.858	0.783–0.941	0.001
≥4	0.539	0.502–0.579	<0.001	0.700	0.641–0.764	<0.001
Unknown	0.621	0.549–0.702	<0.001	0.771	0.678–0.878	<0.001

The difference was statistically significant. OS: overall survival; ACT: adjuvant chemotherapy; HR: hazard ratio; and CI: confidence interval.