Weighted Gene Correlation Network Analysis Identifies Specific Functional Modules and Genes in Esophageal Cancer

Figure 3

Development of a coexpression network and discovery of ESCA-specific coexpression module in the GSE38129 cohort. (a) Sample cluster analysis of 30 paired ESCA tumors and nontumors. (b) The scale-free network topology (left) and mean connectivity (right) following diverse soft threshold power values. (c) Gene dendrogram clustered in line with a dissimilarity measure. The upper panel presents gene tree and the bottom panel is indicative of gene modules signed by diverse colors. (d) Heatmap displays the relationship between coexpression modules and clinical trait-tissue type. The upper number in each cell presents Pearson correlation coefficient between each module and tissue type. Additionally, the lower number represents the value. (e) Scatter plots showing the association between module membership and gene significance for normal tissue type for the turquoise module. (f) Scatter plots present the correlation between module membership and gene significance for ESCA tumor tissue type for the turquoise module.

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