Plumbagin Enhances the Radiosensitivity of Tongue Squamous Cell Carcinoma Cells via Downregulating ATM

Figure 1

The effect of PL and/or IR on TSCC cell viability. (a, d) SCC9 and CAL27 cells were treated with 0.625–20 μM PL for 12, 24, and 48 hr. (b, e) Combination treatment of various doses of PL and IR for 24 hr in SCC9 and CAL27 cells. (c, f) Histograms of the cell viability after the combination treatment of 1.25 μM PL and 1–8 Gy IR for 24 hr. (g, i) SCC9 and CAL27 cells were treated with IR, PL, and IR + PL for 24 hr. (h, j) Colony formation quantification of TSCC cells with PL or combined with IR. .

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