Plumbagin Enhances the Radiosensitivity of Tongue Squamous Cell Carcinoma Cells via Downregulating ATM

Figure 4

Combined PL and IR inhibit ATM signaling in TSCC cells. (a) Representative bolts of ATM, p-ATM, NF-, and p-NF- in SCC9 and CAL27 cells after the treatment of IR, PL, and IR + PL for 24 hr. (c) Representative bolts of ATM, p-ATM, NF-, and p-NF- in SCC9 and CAL27 cells after the treatment of CQ, KU, PL + IR, PL + IR + CQ, and PL + IR + KU for 24 hr. (b, d) Bar graphs showing the ratio of p-AMT/ATM and p-NF-/NF- when the cells were treated with various groups for 24 hr. , , and .

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