LMTK2 as Potential Biomarker for Stratification between Clinically Insignificant and Clinically Significant Prostate Cancer

Table 2

Univariate and multivariate logistic regression of the diagnostic factors for csPC cases.

Univariate analysis	Binary logistic regression			AUC
Variable	OR	value	Sensitivity, specificity	Area (95% CI)	value
bLMTK2:
>−3.80	0.39	0.03	57%	0.61 (0.50–0.73)	0.055
≤−3.80	—	Ref.	67%
lg(PSAd)	18.5	0.002	60%	0.69 (0.58–0.80)	0.001
			74%
Multivariate analysis	Binary logistic regression			AUC
Variables	OR	value	Sensitivity, specificity	Area (95% CI)	value
bLMTK2:
>−3.80	0.28	0.007	64%, 67%	0.74 (0.64–0.84)	<0.001
≤−3.80	—	Ref.
lg(PSAd)	32.5	0.001

OR, odds ratio; AUC, area under the receiver operating characteristics curve; CI, confidence interval. Ref., reference group. lg(PSAd) denotes logarithm of base 10 for PSA density value, ng/ml; bLMTK2 denotes the gene expression level as binary variable.