Evaluation of Hippo Pathway and CD133 in Radiation Resistance in Small-Cell Lung Cancer

Figure 3

YAP1 may induce radiation resistance in SCLC. The survival rates of SCLC increased significantly (a) following different doses of IR when YAP1 was hyperactive and (b) at different time points after IR exposure of 6 Gy when YAP1 was hyperactive. The survival rates of SCLC decreased significantly (c) following different doses of IR when YAP1 was inhibited and (d) at different time points after IR exposure of 6 Gy when YAP1 was inhibited. (e) Representative pictures demonstrating the different survived rates after IR exposure of 6 Gy when YAP1 was hyperactive or inhibited. (f) Bar graphs showing the different survival rates after IR exposure of 6 Gy when YAP1 was hyperactive or inhibited. (g) Representative pictures demonstrating that a lower number of colonies survived and formed when YAP1 was inhibited following different doses of IR. (h) Line chart showing a lower number of colonies survived and formed when YAP1 was inhibited following different doses of IR.