Evaluation of Hippo Pathway and CD133 in Radiation Resistance in Small-Cell Lung Cancer

Figure 4

CD133 may be controlled by the expression of YAP1 and CD133 may be associated with the radiation resistance of SCLC. (a) The percent of CD133⁺ changed when YAP1 was hyperactive or inhibited in SCLC. (b) The percent of CD133⁺ increased significantly when YAP1 was hyperactive. (c) The expression of YAP1 and CD133 in SCLC patients after the paraffin-embedded tissues were sectioned continuously. (d) The percent of CD133⁺ after CD133⁺ cells selection in H69. The survival rate of CD133⁺ increased significantly (e) following different doses of IR as compared to that of CD133⁻ and (f) at different time points after IR exposure of 6 Gy as compared to that of CD133⁻. (g) Representative pictures demonstrating the different survival rates between CD133⁺ and CD133⁻cells. (h) Bar graphs showing the different survival rates between CD133⁺ and CD133⁻ cells.