| Variables | Univariate analysis | Multivariate analysis | HR (95% CI) | value | HR (95% CI) | value |
| Sex (F/M) | 0.819 (0.465, 1.442) | 0.489 | — | — | Age (≥65/<65) | 1.723 (0.912, 3.256) | 0.094 | 3.317 (1.430, 7.694) | 0.005 | ECOG (1/0) | 1.169 (0.693, 1.972) | 0.559 | — | — | LDH (≥250/<250 U/L) | 0.816 (0.293, 2.271) | 0.697 | — | — | CEA (≥5/<5 ng/ml) | 2.881 (1.273, 6.523) | 0.011 | 2.107 (0.798, 5.563) | 0.132 | Tumor location | | 0.189 | — | — | Upper 1/3 | reference | | | | Middle 1/3 | 1.748 (0.741, 4.121) | 0.202 | | | Lower 1/3 | 0.966 (0.487, 1.917) | 0.922 | | | Total stomach | 2.114 (0.733, 6.096) | 0.166 | | | Surgery type (total/subtotal) | 2.287 (1.354, 3.864) | 0.002 | 1.738 (0.871, 3.468) | 0.117 | Size (≥5/<5 cm) | 1.103 (1.007, 1.207) | 0.035 | 0.605 (0.325, 1.129) | 0.114 | Grade (poor/moderate) | 2.187 (1.192, 4.010) | 0.011 | 1.457 (0.646, 3.286) | 0.364 | Borrmann classification | | 0.103 | | 0.266 | I | <0.001 | 0.973 | <0.001 | 0.977 | II | 0.301 (0.116,0.779) | 0.013 | 0.284 (0.074, 1.092) | 0.067 | III | 0.586 (0.300,1.145) | 0.118 | 0.537 (0.252, 1.144) | 0.107 | IV | reference | | reference | | pTNM (III/II) | 4.685 (1.866, 11.762) | 0.001 | 3.407 (1.135, 10.228) | 0.029 | LVI (+/−) | 1.278 (0.738, 2.214) | 0.381 | — | — | PNI (+/−) | 1.588 (0.916, 2.754) | 0.099 | 0.955 (0.504, 1.965) | 0.988 | IS | | <0.001 | | <0.001 | Low | reference | | reference | | Intermediate | 0.226 (0.122, 0.417) | <0.001 | 0.256 (0.119, 0.549) | <0.001 | High | 0.068 (0.024, 0.189) | <0.001 | 0.087 (0.028, 0.273) | <0.001 |
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