Exosomal lncRNA SCIRT/miR-665 Transferring Promotes Lung Cancer Cell Metastasis through the Inhibition of HEYL

Figure 1

Identification of exosomal miRNAs associated with lung-cancer-induced MPE. (a) Electron microscopy analysis and (b) nanoparticle tracking analysis of exosomes from pleural effusions. Scale bar: 100 nm. (c) Western blotting analysis of CD63, TSG101, and calnexin in exosomes. (d) Cluster analysis heatmap of exosomal miRNAs from MPE (NSCLC and SCLC) and BPE samples. (e) The Venn diagram was used to identify overlapping and nonoverlapping exosomal miRNAs among NSCLC, SCLC, and TB effusions. (f) Upregulated exosomal miRNAs from both NSCLC and SCLC patients.

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