Sites of Synchronous Distant Metastases, Prognosis, and Nomogram for Small Cell Lung Cancer Patients with Bone Metastasis: A Large Cohort Retrospective Study

Table 2

Univariate and multivariate Cox analyses in SCLC patients with BM.

		Univariate Cox analysis				Multivariate Cox analysis
		HR	95% CI			HR	95% CI		P
Age
	<66
	66–79	1.216	1.138	1.300	≤0.01	1.155	1.080	1.235	≤0.01
	>79	1.865	1.678	2.073	≤0.01	1.344	1.204	1.500	≤0.01
Race
	Black
	Others	1.111	0.917	1.346	0.281
	White	1.058	0.935	1.198	0.372
	Unknown	0.670	0.167	2.692	0.572
Sex
	Female
	Male	1.083	1.018	1.153	0.012	1.099	1.031	1.172	≤0.01
Primary site
	Upper lobe
	Middle lobe	0.804	0.675	0.959	0.015	0.806	0.676	0.961	0.016
	Lower lobe	1.021	0.939	1.111	0.621	0.971	0.892	1.056	0.487
	Lung, NOS	1.159	1.063	1.264	≤0.01	1.130	1.036	1.232	≤0.01
	Others	0.988	0.896	1.090	0.811	1.025	0.929	1.131	0.618
Grade
	I
	II	2.220	0.677	7.275	0.188
	III	1.926	0.858	4.325	0.112
	IV	1.883	0.842	4.214	0.123
	Unknown	1.994	0.895	4.444	0.091
Laterality
	Bilateral
	Left	0.923	0.702	1.213	0.565
	Right	0.927	0.706	1.218	0.588
	Unknown	1.128	0.837	1.520	0.430
T stage
	T1
	T2	1.075	0.938	1.233	0.299
	T3	1.156	1.007	1.327	0.040
	T4	1.148	1.009	1.306	0.036
	Unknown	1.184	1.033	1.356	0.015
N stage
	N0
	N1	0.983	0.829	1.166	0.847
	N2	1.013	0.902	1.139	0.825
	N3	1.015	0.895	1.151	0.814
	Unknown	1.053	0.910	1.220	0.487
Surgery
	No
	Yes	1.018	0.830	1.248	0.864
Radiotherapy
	No
	Yes	0.676	0.633	0.721	≤0.01	0.801	0.747	0.860	≤0.01
Chemotherapy
	No
	Yes	0.249	0.231	0.268	≤0.01	0.272	0.252	0.294	≤0.01
Brain metastasis
	No
	Yes	1.162	1.073	1.259	≤0.01	1.271	1.168	1.384	≤0.01
Liver metastasis
	No
	Yes	1.304	1.224	1.389	≤0.01	1.309	1.227	1.395	≤0.01
Lung metastasis
	No
	Yes	1.154	1.072	1.243	≤0.01
Insurance status
	Uninsured
	Insured	0.755	0.634	0.900	≤0.01
Marital status
	Unmarried
	Married	0.855	0.804	0.911	≤0.01	0.895	0.839	0.954	≤0.01

SCLC, small cell lung cancer; BM, bone metastasis.