Sites of Synchronous Distant Metastases, Prognosis, and Nomogram for Small Cell Lung Cancer Patients with Bone Metastasis: A Large Cohort Retrospective Study

Table 4

Univariate and multivariate Cox regression for overall survival based on treatment modalities and metastatic sites.

Groups (n)	Variables	Level	n	Univariate	value	Multivariate	value
				HR (95% CI)		HR (95% CI)
Bone-only (1832)	Surgery	No	1786
		Yes	46	1.123 (0.829–1.520)	0.454
	Radiotherapy	No	1117
		Yes	715	0.613 (0.554–0.679)	≤0.01	0.784 (0.705–0.873)	≤0.01
	Chemotherapy	No	485
		Yes	1347	0.239 (0.212–0.268)	≤0.01	0.262 (0.231–0.297)	≤0.01
Bone and brain (387)	Surgery	No	377
		Yes	10	1.471 (0.758–2.856)	0.254
	Radiotherapy	No	94
		Yes	293	0.698 (0.546–0.893)	≤0.01
	Chemotherapy	No	97
		Yes	290	0.233 (0.178–0.304)	≤0.01	0.233 (0.178–0.304)	≤0.01
Bone and liver (2157)	Surgery	No	2118
		Yes	39	0.992 (0.713–1.380)	0.962
	Radiotherapy	No	1553
		Yes	604	0.675 (0.611–0.745)	≤0.01	0.794 (0.717–0.878)	≤0.01
	Chemotherapy	No	608
		Yes	1549	0.229 (0.205–0.254)	≤0.01	0.243 (0.218–0.271)	≤0.01
Bone and lung (392)	Surgery	No	383
		Yes	9	0.822 (0.420–1.610)	0.567
	Radiotherapy	No	265
		Yes	127	0.654 (0.523–0.817)	≤0.01	0.777 (0.618–0.976)	0.030
	Chemotherapy	No	119
		Yes	273	0.345 (0.273–0.436)	≤0.01	0.367 (0.289–0.467)	≤0.01
Bone, liver, and brain (469)	Surgery	No	460
		Yes	9	0.919 (0.475–1.781)	0.803
	Radiotherapy	No	165
		Yes	304	0.616 (0.504–0.752)	≤0.01	0.785 (0.637–0.968)	0.024
	Chemotherapy	No	130
		Yes	339	0.247 (0.195–0.311)	≤0.01	0.264 (0.208–0.336)	≤0.01
Bone, lung, and brain (112)	Surgery	No	108
		Yes	4	1.402 (0.513–3.830)	0.510
	Radiotherapy	No	34
		Yes	78	0.557 (0.361–0.859)	≤0.01
	Chemotherapy	No	32
		Yes	80	0.265 (0.168–0.419)	≤0.01	0.210 (0.127–0.348)	≤0.01
Bone, lung, and liver (682)	Surgery	No	666
		Yes	16	0.952 (0.576–1.573)	0.848
	Radiotherapy	No	522
		Yes	160	0.751 (0.626–0.903)	≤0.01
	Chemotherapy	No	224
		Yes	458	0.259 (0.216–0.311)	≤0.01	0.262 (0.218–0.314)	≤0.01
Bone, lung, liver, and brain (222)	Surgery	No	217
		Yes	5	1.145 (0.470–2.786)	0.766
	Radiotherapy	No	86
		Yes	136	0.594 (0.447–0.789)	≤0.01	0.681 (0.508–0.914)	0.011
	Chemotherapy	No	59
		Yes	163	0.246 (0.175–0.345)	≤0.01	0.261 (0.183–0.373)	≤0.01