The Human Positive Cofactor 4 is a Promising Chemotherapeutic Target in Lung Adenocarcinoma

Figure 5

SOX9 acts as a downstream factor of PC4. (a), (b) The expression of SOX9 in the GEO datasets GSE108214 and GSE135083 was analyzed. (c) The correlation between PC4 and SOX9 in multiple cancer types was analyzed online. (d) qRT-PCR analysis revealed the relative SOX9 mRNA expression in PC4-knockdown and PC4-overexpression LUAD cells. (e) Immunofluorescence showed the alteration of SOX9 in PC4-knockdown PC-9 cells. (f) The expression of apoptotic proteins was analyzed after PC-9 PC4-knockdwon and SOX9-overexpression cells were treated with cisplatin.  < 0.05.

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