The Human Positive Cofactor 4 is a Promising Chemotherapeutic Target in Lung Adenocarcinoma

Figure 8

PC4 destabilizes HIF-1α upon cisplatin treatment. (a) The HIF-1α protein level was determined by western blot in PC4-knockdown and PC4-overexpression LUAD cells. (b) Increasing concentrations of cisplatin were added into PC4-knockdown and PC4-overexpression LUAD cells for 24 hours. The HIF-1α protein expression was evaluated by western blot.  < 0.05.

(a)

(b)