Developing a 5-Gene Signature Related to Pyroptosis for Osteosarcoma Patients

Figure 6

Application of the 5-gene prognostic model in the TARGET-OS dataset. (a) A decision tree based on the prognostic model and metastasis. (b) Kaplan–Meier survival curve of C1 to C4 subgroups. (c, d) The distribution in high- and low-PPRS groups and alive and dead groups in C1 to C4 subgroups. ANOVA was conducted. (e, f) Univariate and multivariate Cox regression analyses on ages, genders, metastasis, and PPRS score. (g) A nomogram based on PPRS score and metastasis. (h) Correction for predicted 1-year, 3-year, and 5-year overall survival based on the observed survival. (i) Decision curve analysis (DCA) of the nomogram, metastasis, and PPRS score. (j): AUC values of the nomogram, ages, genders, metastasis, and PPRS score. The log-rank test was conducted in Kaplan–Meier survival analysis (b) and univariate and multivariate Cox regression analysis (e, f). ANOVA test was conducted in (c, d). .

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