TRIP13/FLNA Complex Promotes Tumor Progression and Is Associated with Unfavorable Outcomes in Melanoma

Figure 2

TRIP13 promotes melanoma cell invasion and migration in vitro and in vivo. (a) Transfection efficiency was detected by western blotting. (b) A2058-shNC and A2058-TRIP13 cells were injected into the tail vein of nude mice (). After 21 days, the lungs were dissected and metastatic lesions in the lungs were counted. (c) The migratory ability of melanoma cells with TRIP13 overexpression or knockdown was evaluated with the wound healing assay. (d) The invasive capacity of melanoma cells with TRIP13 overexpression or knockdown was assessed with the transwell assays. , , , and .

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