TRIP13/FLNA Complex Promotes Tumor Progression and Is Associated with Unfavorable Outcomes in Melanoma

Figure 3

TRIP13 induces EMT in melanoma cells. (a) Relationship between N-cadherin, vimentin, Slug, Twist, zinc finger E-box binding homeobox 2 (ZEB2), and TRIP13 expression in patients with melanoma in TCGA database. (b) Shape of melanoma cells with TRIP13 overexpression or knockdown. (c, d) Western blot and immunofluorescence analyses of E-cadherin and N-cadherin expressions in A2058 and MV3 cells expressing TRIP13-negative control shRNA (A2058-shNC) or empty vector (MV3-Vector), or TRIP13 overexpression (A2058-TRIP13) or shRNA (MV3-shTRIP13). .

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