TRIP13/FLNA Complex Promotes Tumor Progression and Is Associated with Unfavorable Outcomes in Melanoma

<div>TRIP13 promotes melanoma cell migration, invasion, and EMT via the PI3K/AKT pathway. (a) DEGs in A2058 and MV3 cells expressing <i>TRIP13</i>-negative control shRNA (A2058-shNC) or empty vector (MV3-Vector), or <i>TRIP13</i> overexpression (A2058-TRIP13) or shRNA (MV3-shTRIP13) depicted by volcano plots. (b) Kyoto Encyclopedia of Genes and Genomes pathway analysis of DEGs. (c) Protein levels of TRIP13, p-AKT, and AKT in A2058-shNC, A2058-TRIP13, MV3-Vector, and MV3-shTRIP13 cells detected by western blotting. (d, e) Migration and invasion of A2058-shNC and A2058-TRIP13 cells treated with LY294002. 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Journal of Oncology

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Figure 4

Figure 4: TRIP13/FLNA Complex Promotes Tumor Progression and Is Associated with Unfavorable Outcomes in Melanoma 