Ai-Tong-An-Gao-Ji and Fisetin Inhibit Tumor Cell Growth in Rat CIBP Models by Inhibiting the AKT/HIF-1α Signaling Pathway

Figure 2

The key components and core targets of ATAGJ in treating bone cancer pain were analyzed by network pharmacology: (a) interaction analysis of 28 proteins; (b) drug-component-target gene network diagram. ATAGJ refers to compound MQZ, BP, ZJC, SF, WLZ, and XJ. MQZ refers to the borneol, spina gleditsiae, pillworm, faeces trogopterori, resina draconis, and semen strychni; (c) molecular docking between fisetin and AKT; (d) molecular docking between fisetin and VEGFA.

(a)

(b)

(c)

(d)