RETRACTED: Cholesterol Promotes Colorectal Cancer Growth by Activating the PI3K/AKT Pathway

Figure 5

Cholesterol stimulates the progression of CRC via activating the PI3K/AKT. (a) p-AKT and AKT in SW480 and HCT116 cell lines treated with or without cholesterol and in CRC tissues of mice in the ND, HFD, and HFHC groups. (b) p-STAT3, STAT3, p-p38, and p38 in cells and in CRC tissues of mice in the ND, HFD, and HFHC groups. (c) IC₅₀ values of BAY80-6946. (d) Cell viability was determined in SW480 and HCT116 cells treated with cholesterol or for 0, 1, 2, 3, 4, 5, and 6 days. Colony formation ability was also analyzed in cells treated with cholesterol or . (e) Body weight of mice in the ND, HFD, HFHC, and groups. (f) Tumor number and tumor size of mice in the ND, HFD, HFHC, and groups.

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