Research Article

Potential Impact of Cancer Susceptibility Genes on Lung Cancer Metastasis

Table 1

The full name, genomic location, other associated diseases, and gene coefficients in the model.

Cancer typeGene symbolFull nameGenomic locationOther associated diseasesRisk coefficient

LUAD
EPHX1Epoxide hydrolase 1Chr 1Hypercholanaemia, familial, and eclampsia−0.16790078
PRDM2PR/SET domain 2Chr 1Retinoblastoma, Wilms tumour 5−0.02219008
ABHD16AAbhydrolase domain containing 16AChr 6Coronary artery aneurysm and lynch syndrome−0.76723529
VEGFCVascular endothelial growth factor CChr 4Lymphatic malformation 4 and hereditary lymphedema id0.28424844
EXO1Exonuclease 1Chr 1Werner syndrome and Aicardi-Goutieres syndrome0.06614392
ABCA1ATP binding cassette subfamily A member 1Chr 9Tangier disease and Hypoalphalipoproteinemia−0.07512348
DNAJB4DnaJ heat shock protein family (Hsp40) member B4Chr 1Oculopharyngeal muscular dystrophy0.16479705
KRT8Keratin 8Chr 12Liver cirrhosis and cryptogenic cirrhosis0.17566034
HLA-DOBMajor histocompatibility complex, class II, DO BetaChr 6Duodenal obstruction and systemic lupus erythematosus−0.24952808
REXO4REX4 homologue, 3-5 exonucleaseChr 9Conjunctival pigmentation and uterine inversion0.35525721
LUSC
DCBLD1Discoidin, CUB and LCCL domain containing 1Chr 60.3994102
HYKKHydroxylysine kinaseChr 15Tobacco addiction−0.1806394
SLC17A8Solute carrier family 17 member 8Chr 12Deafness, autosomal dominant 25 and autosomal dominant nonsyndromic sensorineural deafness type DFNA1.38588891
HNF1BHNF1 Homeobox BChr 17Renal cysts and diabetes syndrome and Hnf1b-related autosomal dominant tubulointerstitial kidney disease0.13164075
ACEAngiotensin I converting enzymeChr 17Microvascular complications of diabetes 3 and renal tubular dysgenesis0.36932781
DAB2IPDAB2 interacting proteinChr 9Medulloblastoma and arteriosclerosis0.05801815
FOXE1Forkhead box E1Chr 9Hypothyroidism, thyroidal, or athyroidal, with spiky hair and cleft palate and thyroid cancer−0.0386071

Chr: chromosome. Information on genomic location and associated diseases were retrieved from the GeneCards (https://www.genecards.org).