Up-Regulation of SH3TC2 Induced by YTHDF1 Predicts Poor Outcome and Facilitates Cell-Cycle Progress in Colorectal Cancer

Figure 3

SH3TC2 serves as a potential diagnostic biomarker in CRC. (a) The expression of SH3TC2 in 32 CRC tumor tissues and 12 normal tissues was analyzed from GSE9348, . (b) The expression of SH3TC2 in 17 pairs of CRC tumor and normal tissues was analyzed from GSE32323, . (c) The expression of SH3TC2 in 123 CRC tumor tissues and 25 normal tissues was analyzed from GSE21510, . (d) The expression of SH3TC2 in 566 CRC tumor tissues and 19 normal tissues was analyzed from GSE39582, . (e-f) The diagnostic value of SH3TC2 in four independent CRC study cohorts, GSE9348 (e), GSE32323 (f), GSE21510 (g), and GSE39582 (h), was analyzed using the ROC curve. AUC refers to the area under the curve, and the higher the AUC value, the higher the diagnostic value. (i) The expression of SH3TC2 in 12 pairs of CRC tissues was tested by IHC, . (j) The expression of SH3TC2 in 30 pairs of CRC tissues from the TMA cohort was examined by IHC, .

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