Up-Regulation of SH3TC2 Induced by YTHDF1 Predicts Poor Outcome and Facilitates Cell-Cycle Progress in Colorectal Cancer

Figure 4

SH3TC2 promotes cell-cycle progress in CRC. (a) RNA sequencing was performed to investigate the molecular expression changes caused by SH3TC2 knockdown in HCT116 cells. NC refers to HCT116 cells transfected with sh-NC lentivirus, and KD refers to HCT116 cells transfected with sh-SH3TC2#1 lentivirus. (b) Gene enrichment analysis of GO (b) and KEGG (c) was performed based on the RNA sequencing result to explore biological pathways related to SH3TC2. (d) Flow cytometry was utilized to detect cell-cycle changes in HCT116 and SW480 cells following SH3TC2 knockdown.

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