Low Complement Factor H-Related 3 (CFHR3) Expression Indicates Poor Prognosis and Immune Regulation in Cholangiocarcinoma

Table 3

The univariate and multivariate regression analysis of cholangiocarcinoma.

Characteristics	Total ()	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	P value
CFHR3	36	1.265 (0.987-1.621)	0.063	1.252 (0.937-1.672)	0.128
Age	36
≤65	17	Reference
>65	19	1.268 (0.499-3.221)	0.617
Gender	36
Female	20	Reference
Male	16	1.387 (0.544-3.534)	0.494
T stage	36
T1	19	Reference
T2	12	2.612 (0.939-7.263)	0.066
T3	5	0.986 (0.204-4.767)	0.986
N stage	31
N0	26	Reference
N1	5	2.289 (0.602-8.700)	0.224
M stage	33
M0	28	Reference
M1	5	1.650 (0.462-5.891)	0.440
Pathologic stage	36
Stage I	19	Reference
Stage II	9	2.046 (0.646-6.476)	0.223
Stage III	1	0.000 (0.000-Inf)	0.998
Stage IV	7	2.279 (0.719-7.224)	0.162
Histological type	36
Distal	2	Reference
Hilar/perihilar	4	130157029.581 (0.000-Inf)	0.998
Intrahepatic	30	69806426.989 (0.000-Inf)	0.998
CA19-9 level	30
Abnormal	16	Reference
Normal	14	1.003 (0.349-2.883)	0.995
Vascular invasion	34
No	29	Reference
Yes	5	1.764 (0.488-6.372)	0.387
Perineural invasion	33
No	26	Reference
Yes	7	4.264 (1.184-15.352)	0.026	4.871 (1.308-18.139)	0.018