The lncRNA NEAT1/miRNA-766-5p/E2F3 Regulatory Axis Promotes Prostate Cancer Progression

Figure 6

E2F3 was a target gene of miRNA-766-5p. (a) The binding sites between miRNA-766-5p and E2F3 predicted by StarBase. (b) The interaction between miRNA-766-5p and E2F3 testified by the luciferase reporter assay. , tumor vs. nontumor. (c) The level of E2F3 in PCa tissues. , miR-766-5p mimic vs. NC mimic. (d) The level of E2F3 in PCa cells. , P4E6, LNCaP, PC3, and DU145 vs. RWPE-1. (e) The mRNA level of E2F3 in miRNA-766-5p mimic treated cells. , miR-766-5p mimic vs. NC mimic. (f) The protein level of E2F3 in miRNA-766-5p mimic treated cells. , miR-766-5p mimic vs. NC mimic. (g) Pearson’s correlation analysis demonstrated the correlation of miRNA-766-5p expression with E2F3.

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