CKAP2L Promotes Esophageal Squamous Cell Carcinoma Progression and Drug-Resistance by Modulating Cell Cycle

Figure 1

CKAP2L is overexpressed in ESCC tissues and cell lines. (a) Volcano plot for differentially expressed genes in ESCC on the basis of GSE17351. The fold change (FC) of genes was assessed by log transformation. |logFC| >2.5 and adjusted were defined as the screened threshold. (b) The data were from TCGA & GTEx database and analyzed by the GEPIA website, the expression of CKAP2L was upregulated in tumor tissues compared with normal tissues (). (c) Expression levels of CKAP2L in clinical samples were detected by RT-qPCR. by student’s T-test. (d) Expression levels of CKAP2L in ESCC cell lines were detected by RT-qPCR. by student’s t-test versus Het-1A. (e) Western blot analyses the protein expression of CKAP2L in ESCC cells compared with the normal cells Het-1A. GAPDH was used as a loading control in the western blot. The data were expressed as mean ± SD (n = 3), .

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