TEAEs Studies, n RAM, n Con, n OR (95% CI) Events Total Events Total Fatigue 9 Grade 1-2 1686 3526 1269 2923 1.14 [1.03, 1.27] 0.01 Grade ≧3 383 3526 224 2923 1.44 [1.21, 1.71] <0.00001 Hypertension 5 Grade 1-2 174 1422 63 1279 2.55 [1.89, 3.44] <0.00001 Grade ≧3 131 1422 29 1279 4.25 [1.57, 11.53] 0.004 Neuropathy 4 Grade 1-2 349 1741 320 1740 1.12 [0.94, 1.33] 0.21 Grade≧3 49 1741 30 1740 1.66 [1.05, 2.62] 0.03 Decreased appetite 11 Grade 1-2 1098 4040 743 3293 1.34 [1.20, 1.50] <0.00001 Grade≧3 143 4040 55 3293 2.10 [1.52, 2.90] <0.00001 Abdominal pain 9 Grade 1-2 546 3067 451 2686 1.06 [0.82, 1.37] 0.65 Grade ≧3 89 3067 69 2686 1.13 [0.82, 1.56] 0.45 Nausea 9 Grade 1-2 966 3052 850 2796 1.13 [1.01, 1.27] 0.04 Grade ≧3 52 3052 61 2796 0.84 [0.57, 1.22] 0.36 Alopecia 6 Grade 1-2 643 2255 626 2110 0.94 [0.71, 1.24] 0.66 Grade ≧3 0 3782 0 3028 0.34 [0.04, 3.26] 0.35 Diarrhoea 9 Grade 1-2 887 3052 823 2796 1.11 [0.86, 1.44] 0.41 Grade ≧3 144 3052 107 2796 1.52 [0.95, 2.43] 0.08 Epistaxis 6 Grade 1-2 596 2128 151 1622 3.58 [2.94, 4.36] <0.00001 Grade ≧3 1 2128 3 1622 1.53 [0.06, 37.57] 0.80 Vomiting 9 Grade 1-2 593 3067 495 2686 1.09 [0.95, 1.25] 0.21 Grade≧3 70 3067 80 2686 0.78 [0.56, 1.08] 0.13 Peripheral oedema 5 Grade 1-2 433 1957 206 1846 2.28 [1.90, 2.73] <0.00001 Grade ≧3 10 1957 3 1846 2.37 [0.74, 7.58] 0.15 Constipation 8 Grade 1-2 481 2744 414 2371 1.01 [0.87, 1.17] 0.89 Grade ≧3 9 2744 20 2371 0.41 [0.19, 0.88] 0.02 Stomatitis 6 Grade 1-2 871 2714 420 2347 2.00 [1.57, 2.54] <0.00001 Grade≧3 108 2714 31 2347 2.92 [1.94, 4.40] <0.00001 Pyrexia 8 Grade 1-2 427 2729 265 2481 1.55 [1.32, 1.83] <0.00001 Grade ≧3 11 2729 7 2481 1.41 [0.57, 3.48] 0.45 Proteinuria 5 Grade 1-2 270 1376 90 1240 2.89 [1.98, 4.21] <0.00001 Grade ≧3 24 1376 2 1240 6.26 [2.05, 19.10] 0.001 Dyspnoea 6 Grade 1-2 251 2174 245 1950 0.96 [0.79, 1.16] 0.65 Grade ≧3 44 2174 67 1950 0.82 [0.32, 2.09] 0.68 Rash 4 Grade 1-2 137 1335 131 1347 1.06 [0.82, 1.37] 0.65 Grade ≧3 3 1335 8 1347 0.45 [0.14, 1.46] 0.18 Weight decreased 3 Grade 1-2 8 1149 5 1002 1.37 [0.49, 3.80] 0.55 Grade ≧3 164 1149 106 1002 1.31 [0.83, 2.05] 0.25 Cough 6 Grade 1-2 356 2274 261 2121 1.37 [1.15, 1.63] 0.0004 Grade ≧3 5 2274 7 2121 0.76 [0.27, 2.11] 0.60 Back pain 4 Grade 1-2 143 1505 104 357 1.24 [0.95, 1.62] 0.12 Grade ≧3 12 1505 7 1357 1.67 [0.67, 4.16] 0.27 Hypoalbuminaemia 3 Grade 1-2 150 897 56 750 2.05 [1.47, 2.87] <0.0001 Grade ≧3 8 897 4 750 1.70 [0.54, 5.30] 0.36 Myalgia 2 Grade 1-2 4 954 5 947 0.81 [0.23, 2.82] 0.74 Grade ≧3 112 954 76 947 1.52 [1.12, 2.07] 0.007 Ascites 3 Grade 1-2 109 801 48 700 2.20 [1.53, 3.16] <0.0001 Grade≧3 33 801 26 700 1.14 [0.67, 1.94] 0.63 Headache 5 Grade 1-2 252 1957 148 1846 1.98 [1.17, 3.35] 0.01 Grade ≧3 8 1957 8 1846 0.93 [0.39, 2.22] 0.87 Neutropenia 6 Grade 1-2 724 2816 591 2437 1.16 [1.02, 1.33] 0.03 Grade ≧3 858 2816 572 2437 1.67 [1.20, 2.33] 0.002 Anaemia 6 Grade 1-2 424 2300 469 2170 0.83 [0.71, 0.96] 0.01 Grade ≧3 161 2593 179 2315 0.71 [0.56, 0.89] 0.003 Leucopenia 3 Grade 1-2 218 1277 153 1262 1.50 [1.20, 1.88] 0.0004 Grade ≧3 190 1277 116 1262 1.69 [0.97, 2.94] 0.06 Thrombocytopenia 6 Grade 1-2 381 2341 175 2331 2.47 [2.04, 3.00] <0.00001 Grade ≧3 78 2341 26 2331 3.02 [1.94, 4.72] <0.00001
