Screening of the Key Genes for the Progression of Liver Cirrhosis to Hepatocellular Carcinoma Based on Bioinformatics

Figure 6

The prognostic potentials of the genes (a) BUB1B, (b) MELK, (c) MAD2L1, (d) CCNB2, (e) NUSAP1, (f) RRM2, (g) TTK, (h) HMMR, (i) CCNA2, and (j) KIF2C were investigated. Patients diagnosed with HCC having higher levels of expression of these genes had lower cancer-free intervals as compared to patients with lower expression levels of these genes (logrank test, ). Based on the Cox pH model, HR was determined, and the 95% CI was shown as a dotted line.

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