Machine Learning of Dose-Volume Histogram Parameters Predicting Overall Survival in Patients with Cervical Cancer Treated with Definitive Radiotherapy

Table 1

Summarization and univariate Cox-pH analysis of clinical factors for overall survival.

Features	Grades	Median (IQR) or No (%)	HR (95%CI)	value
OS (months)		25.78 (14.26 – 41.57)
Censor	0	103 (80.47%)
	1	25 (19.53%)
Age (years)		53 (46 – 63)	0.08 (9.08e − 04 – 6.87)	0.27
ECOG	0 and 1	112 (87.5%)	Reference
	2	16 (12.5%)	1.74 (0.65 – 4.65)	0.27
FIGO 2018 stage	II	36 (28.12%)	Reference
	III	83 (64.84%)	1.82 (0.61 – 5.43)	0.28
	IV	9 (7.03%)	5.82 (1.44 – 23.48)	0.01
Body mass index		23.05 (20.11 – 25.01)	1.06e  −  03 (1.75e − 06 – 0.65)	0.04
EBRT technique	3D-CRT	27 (21.09%)	Reference
	RapidArc	101 (78.91%)	0.9 (0.38 – 2.14)	0.81
Induction chemotherapy	Without	102 (79.69%)	Reference
	With	26 (20.31%)	1.4 (0.52 – 3.8)	0.51
Concurrent chemotherapy	Without	20 (15.62%)	Reference
	With	108 (84.38%)	0.7 (0.24 – 2.05)	0.52
Pre-RT regional lymph node metastasis	Without	43 (33.59%)	Reference
	With	85 (66.41%)	1.48 (0.62 – 3.57)	0.38
White blood cells (10^3 cells/ul)		6.59 (5.12 – 8.12)	1.85 (0.23 – 14.72)	0.56
Hemoglobin (g/L)		117.5 (102.5 – 129.25)	8.96e  −  04 (4.34e − 06 – 0.18)	9.84e-03
Platelets (10^3 cells/ul)		260 (217.5 – 318)	2.29 (0.17 – 30.44)	0.53
Neutrophils (10^3 cells/ul)		4.24 (3.03 – 5.65)	2.61 (0.51 – 13.42)	0.25
Lymphocytes (10^3 cells/ul)		1.74 (1.3 – 2.08)	0.11 (9.11e − 03 – 1.22)	0.07
Monocytes (10^3 cells/ul)		0.34 (0.25 – 0.44)	0.34 (0.06 – 1.94)	0.22

Abbreviations: OS = overall survival; EBRT = external beam radiation therapy; 3D-CRT = three-dimensional conformal radiotherapy; RT = radiotherapy; ECOG = Eastern Cooperative Oncology Group; FIGO=International Federation of Gynecology and Obstetrics; IQR = interquartile range; HR = hazard ratio; CI = confidence interval.