Machine Learning of Dose-Volume Histogram Parameters Predicting Overall Survival in Patients with Cervical Cancer Treated with Definitive Radiotherapy
Table 2
Summarization and univariate Cox-pH analysis of DVH parameters for overall survival.
Features
Grades
Median (1st – 3rd) or Num (%)
HR (95% CI)
value
GTV_P dmean (Gy)
47.1 (46.6 – 49.21)
1.26e + 04 (1.3e – 03 – 1.22e + 11)
0.25
GTV_P dmax (Gy)
53.2 (48.6 – 57.8)
5.93e + 03 (0.19 – 1.86e + 08)
0.1
GTV_P volume (cm3)
75 (52.18 – 122.58)
9.8 (2.67 – 35.91)
5.77e– 04
PTV_4500 dmean (Gy)
47.62 (46.84 – 50.05)
6.68e + 03 (8.8e – 03 – 5.07e + 09)
0.2
PTV_4500 dmax (Gy)
58.5 (56.98 – 59.2)
9.2e + 03 (0.02 – 4.07e + 09)
0.17
PTV_4500 volume (cm3)
1.38e + 03 (1.25e + 03 – 1.54e + 03)
181.2 (1.98 – 1.66e + 04)
0.02
GTV_N dmean (Gy)
None
51 (39.84%)
Reference
Low
39 (30.47%)
2.69 (1.06 – 6.8)
0.04
High
38 (29.69%)
1.12 (0.39 – 3.24)
0.83
GTV_N dmax (Gy)
None
51 (39.84%)
Reference
Low
42 (32.81%)
2 (0.76 – 5.27)
0.16
High
35 (27.34%)
1.59 (0.59 – 4.24)
0.36
PTV_5500 dmean (Gy)
None
56 (43.75%)
Reference
Low
36 (28.12%)
1.81 (0.67 – 4.89)
0.24
High
36 (28.12%)
1.37 (0.54 – 3.51)
0.51
PTV_5500 dmax (Gy)
None
56 (43.75%)
Reference
Low
37 (28.91%)
1.79 (0.66 – 4.84)
0.25
High
35 (27.34%)
1.38 (0.54 – 3.53)
0.5
Body dmean (Gy)
12.11 (10.67 – 13.9)
544.54 (7.9 – 3.75e + 04)
3.53e – 03
Body dmax (Gy)
58.5 (56.98 – 59.23)
2.89e + 04 (0.05 – 1.54e + 10)
0.13
Body (%)
45.32 (42.21 – 49.51)
991 (8.97 – 1.1e + 05)
4.06e – 03
Body (%)
6.77 (5.37 – 9.47)
11.34 (1.13 – 114.19)
0.04
Body volume (cm3)
2.45e+04 (2.11e + 04 – 2.84e + 04)
0.02 (1.5e–04 – 2.4)
0.11
Bones dmean (Gy)
29.22 (27.84 – 31.88)
74.13 (0.15 – 3.58e + 04)
0.17
Bones dmax (Gy)
58.1 (53.88 – 58.8)
3.35e + 03 (0.01 – 1.04e + 09)
0.21
Bones V5 (%)
96.79 (95.69 – 98.5)
1.62e + 13 (1.29e-09 – 2.04e + 35)
0.24
Bones V45 (%)
13.77 (10.73 – 20.26)
3.12 (0.66 – 14.75)
0.15
Bones volume (cm3)
1.17e + 03 (1.07e + 03 – 1.28e + 03)
123.26 (0.12 – 1.23e + 05)>
0.17
dmax = maximum dose; dmean = mean dose; GTV_P or GTV_N = gross tumor volume of primary tumor or regionally metastatic lymph nodes, respectively; HR = hazard ratio; CI = confidence interval; PTV_4500 or PTV_5500 = planning target volume receiving prescription dose of 45 Gy or 55 Gy, respectively; or = the relative volumes (in percentage) covered by dose levels of ≥5 Gy or 45 Gy, respectively.
