circSYPL1 Promotes the Proliferation and Metastasis of Hepatocellular Carcinoma via the Upregulation of EZH2 Expression by Competing with hsa-miR-506-3p

<div>Knockdown of circSYPL1 inhibits the growth and metastasis of tumor xenografts. (a) Photographs of PLC-PRF-5 isolated from animal models treated with circSYPL1 siRNA or a negative control siRNA. (b) Growth rates of circSYPL1 or negative control siRNA-treated PLC-PRF-5. (c) Tumor mass of PLC-PRF-5 in groups treated with circSYPL1 or negative control siRNAs. (d) HE is staining analysis of lung metastasis in groups treated with circSYPL1 or negative control siRNAs. (e) Immunohistochemistry staining analysis of tumor proliferation (Ki-67) in groups treated with circSYPL1 or negative control siRNAs.</div>

Journal of Oncology

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Figure 3: circSYPL1 Promotes the Proliferation and Metastasis of Hepatocellular Carcinoma via the Upregulation of EZH2 Expression by Competing with hsa-miR-506-3p 

Figure 3 | circSYPL1 Promotes the Proliferation and Metastasis of Hepatocellular Carcinoma via the Upregulation of EZH2 Expression by Competing with hsa-miR-506-3p 