circSYPL1 Promotes the Proliferation and Metastasis of Hepatocellular Carcinoma via the Upregulation of EZH2 Expression by Competing with hsa-miR-506-3p

<div>circSYPL1, miR-506-3p interactions. (a) miR-506-3p (orange) and circSYPL1 interacting sequences (blue). (b) Luciferase assays to demonstrate that circSYPL1 is directly targeted to miR-506-3p. (c) RNA pull-down assay to determine the interactions between circSYPL1 and miR-506-3p using a biotinylated circSYPL1 probe. (d) RNA pull-down assay to determine whether the miR-506-3p biotin probe interacts with circSYPL1. (e) qPCR demonstrating miR-506-3p expression in cells after treatment with circSYPL1 siRNA or its recombinant overexpression plasmid. (f) qPCR analysis showing the levels of miR-506-3p in HCC and surrounding tissues.</div>

Journal of Oncology

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Figure 4: circSYPL1 Promotes the Proliferation and Metastasis of Hepatocellular Carcinoma via the Upregulation of EZH2 Expression by Competing with hsa-miR-506-3p 

Figure 4 | circSYPL1 Promotes the Proliferation and Metastasis of Hepatocellular Carcinoma via the Upregulation of EZH2 Expression by Competing with hsa-miR-506-3p 