circSYPL1 Promotes the Proliferation and Metastasis of Hepatocellular Carcinoma via the Upregulation of EZH2 Expression by Competing with hsa-miR-506-3p

Figure 5

miR-506-3p targets EZH2. (a) The sequences of miR-506-3p and EZH2 are connected vertically; the seed sequence and corresponding binding sites are shown. (b) Luciferase experiments to show miR-506-direct 3p′s targeting of EZH2. (c) RNA pull-down assay to determine whether the miR-506-3p biotin probe interacts with EZH2. (d) qPCR analysis demonstrating the expression level of EZH2 in HCC and surrounding tissues. (e) Pearson’s correlation analysis demonstrating that EZH2 and miR-506-3p have a negative connection. (f) Pearson’s correlation analysis demonstrating that EZH2 and circSYPL1 have a positive correlation.

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