circSYPL1 Promotes the Proliferation and Metastasis of Hepatocellular Carcinoma via the Upregulation of EZH2 Expression by Competing with hsa-miR-506-3p

Figure 6

miR-506-3p overexpression could reverse the upregulation of EZH2 induced by circSYPL1. (a) qPCR showing the expression of miR-506-3p in PLC-PRF-5 cells treated with negative control mimics and miR-506-3p mimics. (b) qPCR showing the expression of miR-506-3p in HepG2 cells treated with negative control mimics and miR-506-3p mimics. (c) qPCR showing the expression of EZH2 in PLC-PRF-5 cells treated with negative control mimics and miR-506-3p mimics. (d) qPCR showing the expression of EZH2 in HepG2 cells treated with negative control mimics and miR-506-3p mimics. (e) qPCR showing the expression of EZH2 in PLC-PRF-5 cells after treating with negative control plasmid and circSYPL1 overexpressed plasmid. (f) qPCR showing the expression of EZH2 in HepG2 cells treated with a negative control plasmid or a circSYPL1 overexpressed plasmid. (g) qPCR analysis demonstrating the levels of expression of EZH2 in PLC-PRF-5 cells treated with a negative control plasmid as well as its mimics, circSYPL1 overexpressed plasmid and negative control mimics, and circSYPL1 overexpressed plasmid and miR-506-3p mimics. (h) qPCR showing the expression of EZH2 in HepG2 cells treated with negative control plasmid and negative control mimics, circSYPL1 overexpressed plasmid and negative control mimics, and circSYPL1 overexpressed plasmid and miR-506-3p mimics.

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