A Novel Nomogram and Risk Classification System Predicting the Cancer-Specific Survival of Muscle-Invasive Bladder Cancer Patients after Partial Cystectomy
Table 2
Univariate and multivariate regression analyses for CSM.
Characteristics
Univariate analysis
Multivariate analysis
HR (95% CI)
value
HR (95% CI)
value
Age
<60
Ref.
Ref.
60–70
1.311 (0.862–1.994)
0.206
1.143 (0.743–1.759)
0.544
70–80
1.864 (1.249–2.782)
0.002※
1.633 (1.075–2.479)
0.021※
>80
2.705 (1.841–3.975)
<0.001※
2.289 (1.525–3.434)
<0.001※
Sex
Female
Ref.
Male
0.926 (0.719–1.192)
0.551
Race
White
Ref.
Black
1.081 (0.731–1.599)
0.697
Others
0.844 (0.529–1.346)
0.476
Marital status
Married
Ref.
SDW
1.267 (0.968–1.657)
0.084
Single
1.155 (0.804–1.659)
0.436
Grade
Grade I or Grade II
Ref.
Grade III or Grade IV
1.891 (1.281–2.793)
0.001※
Histology
TCC
Ref.
Ref.
SCC
1.787 (1.183–2.699)
0.006※
2.447 (1.537–3.894)
<0.001※
Adenocarcinoma
0.440 (0.287–0.675)
<0.001※
0.818 (0.468–1.428)
0.479
T Stage
T2
Ref.
Ref.
T3
3.102 (2.309–4.168)
<0.001※
3.395 (2.508–4.597)
<0.001※
T4
5.288 (3.586–7.798)
<0.001※
3.956 (2.668–5.866)
<0.001※
N stage
2.668–5.866
N0
Ref.
Ref.
N1 or N2 or N3
2.019 (1.449–2.813)
<0.001※
2.277 (1.568–3.308)
<0.001※
M Stage
M0
Ref.
Ref.
M1
6.426 (4.030–10.247)
<0.001※
4.872 (2.965–8.007)
<0.001※
Tumor size
<3 cm
Ref.
Ref.
>3 cm
1.475 (1.169–1.861)
0.001※
1.334 (1.055–1.688)
0.016※
Number of tumor
Single
Ref.
Multiple
0.961 (0.756–1.223)
0.749
Radiotherapy
No/unknown
Ref.
Ref.
Yes
1.379 (1.003–1.895)
0.048※
1.059 (0.761–1.473)
0.734
Chemotherapy
No/unknown
Ref.
Yes
0.908 (0.710–1.162)
0.444
Regional nodes examined
Non
Ref.
Ref.
1–3
0.678 (0.522–0.879)
0.003※
0.568 (0.396–0.815)
0.002※
>3
0.745 (0.540–1.029)
0.074
0.538 (0.406–0.713)
<0.001※
TCC: transitional cell carcinoma, SCC: squamous cell carcinoma; other races: American Indian, Alaska Native, Asian, and Pacific Islander; SDW: separated, divorced, or widowed; ※: statistical difference
