CircFMN2 Boosts Sorafenib Resistance in Hepatocellular Carcinoma Cells via Upregulating CNBP by Restraining Ubiquitination

Figure 1

CircFMN2 was upregulated in MDR cells. The influence of circFMN2 on cell proliferation and apoptosis in multidrug-resistant cells and nonresistant cells. The level of circFMN2 assessed via RT-qPCR (a), cell proliferation measured by CCK-8 assay (b), colony formation ability (c) and (d), and cell apoptosis analyzed by flow cytometry (e) and TUNEL assay (f), (g) in the study groups. , vs. control group; ^##, , ^###, vs. circFMN2-NC group; ^&, ^&&, ^&&& vs. MDR group; ^$, , ^$$, , ^$$$, vs. MDR + siRNA-NC group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)