Digital Image Analysis-Based Evaluation of Claudin-1 and Claudin-7 Delocalization in Cutaneous Squamous Cell Carcinoma and in Its Precancerous State

Figure 2

Data correlation analysis. (a) Scatterplot matrix indicating correlations within the entire data set (all four groups: sun-exposed skin, AK, BD, and SCC). Pairwise correlation analyses include the tight junction protein (TJPs) characteristics of membrane (Claudin-1-M, Claudin-7-M), cytoplasm (Claudin-1-C, Claudin-7-C), and nucleus (Claudin-1-N, Claudin-7-N) and signaling pathway proteins (p-ERK, p-AKT, and p-mTOR). Data about different groups is represented by different colors (sun-exposed skin, green; AK, yellow; BD, blue; SCC, red). The red line represents the pairwise linear regression slope, while the pink shaded clouds represent the 95% bivariate normal density ellipse. (b) Heatmap representation for the data set.

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