Digital Image Analysis-Based Evaluation of Claudin-1 and Claudin-7 Delocalization in Cutaneous Squamous Cell Carcinoma and in Its Precancerous State

Table 1

Staining expression value of tight junction proteins and signaling pathway proteins.

Specimens	Claudin-1		Claudin-7		p-ERK		p-AKT		p-mTOR
NS
Mem
IM scores		14		7	—	14	—	4	—	11
Cyto
HP (%)
P (%)
LP (%)
Neg (%)
Nuc
HP (%)
P (%)
LP (%)
Neg (%)
AK
Mem
IM scores		9		10	—	10	—	7	—	10
Cyto
HP (%)
P (%)
LP (%)
Neg (%)
Nuc
HP (%)
P (%)
LP (%)
Neg (%)
BD
Mem
IM scores		14		14	—	13	—	15	—	14
Cyto
HP (%)
P (%)
LP (%)
Neg (%)
Nuc
HP (%)
P (%)
LP (%)
Neg (%)
SCC
Mem
IM scores		11		8	—	10	—	11	—	9
Cyto
HP (%)
P (%)
LP (%)
Neg (%)
Nuc
HP (%)
P (%)
LP (%)
Neg (%)

NS: sun-exposed skin; AK: actinic keratosis; BD: Bowen’s disease; SCC: squamous cell carcinoma; Mem: membrane; Cyto: cytoplasm; Nuc: nucleus; HP: high positive; P: positive; LP: low positive; Neg: negative.