LncRNA UCA1 Promotes the Progression of AML by Upregulating the Expression of CXCR4 and CYP1B1 by Affecting the Stability of METTL14

Figure 6

The expression of CYP1B1 and CXCR4 was affected by METTL14: (a, b) qRT-PCR and western blot were used to detect the expression of CYP1B1 and CXCR4 in AML patients; (c, d) the expression of CYP1B1 and CXCR4 affected by overexpressing METTL14 in both HL60 and U937 cells was detected by qRT-PCR and western blot; (e, f) the expression of CYP1B1 and CXCR4 affected by UCA1 and ACTD was assessed by qRT-PCR and western blot; and (g, h) the expression of CYP1B1 and CXCR4 affected by UCA1 and reversed by METTL14 was detected by western blot and qRT-PCR. The data were presented by mean ± SD.  < 0.05,  < 0.01,  < 0.005,  < 0.001,  < 0.05,  < 0.01,  < 0.005, and  < 0.001.