A Model for Predicting Clinical Prognosis in Patients with WHO Grade 2 Glioma

Table 2

Univariate and multivariate cox regression analyses of training groups.

Variables	Univariate analyses		Multivariate analyses
	HR (95% CI)	values	HR (95% CI)	values
Sex		0.442	NA
Male	Reference
Female	1.284 (0.678–2.430)
Age (years)		0.143	NA
≥40	Reference
<40	1.614 (0.851–3.062)
Preoperative KPS		<0.001		<0.001
≥80	Reference		Reference
<80	5.376 (2.831–10.206)		6.648 (2.184–20.231)
First presenting symptom		<0.001		0.005
Seizures	Reference		Reference
Others	7.069 (3.247–15.389)		3.711 (1.475–9.338)
Extent of resection		<0.001		0.001
Gross total	Reference		Reference
Nontotal resection or biopsy	8.504 (3.742–19.326)		5.521 (1.978–15.408)
Deep location		0.023		0.217
Yes	Reference		Reference
No	0.474 (0.249–0.904)		2.154 (0.637–7.288)
Gross tumor size		0.003		0.009
≥6 cm	Reference		Reference
<6 cm	0.381 (0.200–0.728)		0.391 (0.194–0.788)
Histology		0.623	NA
Astrocytoma	Reference
Oligodendroglioma	0.852 (0.450–1.614)
1p19q		0.623	NA
Codeleted	Reference
Not codeleted	0.852 (0.450–1.614)
IDH		0.006		0.492
Mutant	Reference		Reference
Wildtype	2.678 (1.322–5.425)		1.360 (0.565–3.273)
Chemotherapy		0.609	NA
Yes	Reference
No	1.182 (0.623–2.241)
Radiotherapy		<0.001		0.142
Yes	Reference		Reference
No	3.567 (1.863–6.831)		0.366 (0.096–1.401)

: ; NA: not applicable.