The PARP1 Inhibitor Niraparib Represses DNA Damage Repair and Synergizes with Temozolomide for Antimyeloma Effects

Figure 5

Effects of Nira and/or TMZ on DDR signaling in MM cells. RPMI8226 and NCI-H929 cells were administered TMZ and/or Nira for 48 h at various amounts, and immunoblot was carried out for quantitating proteins. GAPDH was utilized for normalization. TMZ: temozolomide; Nira: niraparib.