The PARP1 Inhibitor Niraparib Represses DNA Damage Repair and Synergizes with Temozolomide for Antimyeloma Effects

Table 1

Combination index data for TMZ and Nira in RPMI8226 cells.

Dose TMZ (μM)	Dose Nira (μM)	Combination effect	CI value
10	3	0.23	0.56554
20	3	0.31	0.58787
30	3	0.52	0.38529
50	3	0.58	0.49207
80	3	0.61	0.6861
100	3	0.68	0.67125

Notes: Combination index (CI) values for TMZ and Nira were based on the Chou–Talalay’s method at 48 h. , , and reflect synergistic, additive, and antagonistic effects, respectively. Independent experiments were performed thrice. Mean value of three replicates. In each condition, standard deviation is less than 10%. Abbreviations: TMZ: temozolomide; Nira: niraparib.