The PARP1 Inhibitor Niraparib Represses DNA Damage Repair and Synergizes with Temozolomide for Antimyeloma Effects

Table 2

Combination index data for TMZ and Nira in NCI-H929 cells.

Dose TMZ (μM)	Dose Nira (μM)	Combination effect	CI value
10	3	0.34	0.42312
20	3	0.55	0.3069
30	3	0.59	0.37772
50	3	0.62	0.54191
80	3	0.71	0.58941
100	3	0.79	0.49808

Notes: Combination index (CI) values for TMZ and Nira were based on the Chou–Talalay’s method at 48 h. , , and reflect synergistic, additive, and antagonistic effects, respectively. Independent experiments were performed thrice. Mean value of three replicates. In each condition, standard deviation is less than 10%. Abbreviations: TMZ: temozolomide; Nira: niraparib.