circNBPF10/miR-224 Axis Regulates PBX3 to Promote the Malignant Progression of Lung Cancer

Figure 3

miR-224 is the target of circNBPF10. (a) Information map of binding sites between circNBPF10 and miR-224. (b) Dual luciferase detection of the binding of circNBPF10 to miR-224 (WT: wild type and MT: mutated type). (c) miRNA pull-down assay confirmed the regulatory relationship between circNBPF10 and miR-224. (d) circNBPF10 overexpression inhibited miR-224 expression. (e) Correlation analysis of circNBPF10 and miR-224 coexpression in lung cancer. (f) miR-224 expression in tumors was detected through qRT-PCR.  < 0.01 and  < 0.001.

(a)

(b)

(c)

(d)

(e)

(f)