The Biocomplex Assembled from Antigen Peptide and Toll-like Receptor Agonist Improved the Immunity against Pancreatic Adenocarcinoma In Vivo

Figure 5

In vivo analysis of the impact of the biocomplex on tumor progression in mice. (a) Tumor size in mice over time with different treatments. (b) Tumor size on day 18 in different groups of mice. (c) The level of CD8+ T cells in mice on day 18. The biocomplex with different N : P ratios were employed for the study (, 1 : 1 and 5 : 1). Assessing the levels of (d) IL-6, (e) IFNɤ, and (f) IL-10. Histological staining showing the impact of the biocomplex on major organs including the (g) kidney, (h) lung, (i) heart, and (j) liver. CTRL : Control (treated with PBS), Scale bar = 50 μm , .

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