Artemin Promotes the Migration and Invasion of Cervical Cancer Cells through AKT/mTORC1 Signaling

Figure 5

Through AKT/mTORC1 signaling, ARTN accelerated the metastasis of CC cells in vivo. (a) “T” denotes metastatic nodules on the lungs images, which were taken from mouse models of metastasis. (b) Kaplan–Meier survival analysis of 12 mice injected with oe-ARTN or ARTN-control SiHa cells by the lateral tail vein (, log-rank test). (c) The lung tissues of mice stained with H&E (original magnifications, ×100 and ×400). (d) In lung sections, IHC staining was performed for ARTN, P-mTOR, P-AKT, and E-cadherin (original magnifications, ×400). (e) Western blot analysis of lung tissues revealing the presence of P-mTOR, P-AKT, vimentin, β-catenin, E-cadherin, and ARTN protein expressions.

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